Memorens – Oral Solution
Oral solution in bottle of 200 ml.
Formulation developed in partnership with the Department of Physical, Earth and Environmental Sciences of the University of Siena.
Memorens® is a food supplement specifically developed for the needs of children and adolescents (5 to 11 years old).
Thanks to natural substances and its phytocomplexes, it may have positive effects on MEMORY and COGNITIVE FUNCTIONS.
How to use
For children from 5 to 10 years, it is recommended to take 20 ml per day in a single administration or divided into two administrations of 10 ml each.
Take with meals (breakfast, lunch or dinner) to increase absorption of its components.
Duration of therapy: use for at least 3 months.
Warnings: do not exceed the recommended daily dose. Keep out of reach of children under the age of three. Supplements are not intended as substitutes for a varied and balanced diet and a healthy lifestyle.
Memorens® Oral Solution contains:
- Maritime Pine
- Royal Jelly
Origin – Bacopa monnieri is a plant that has been traditionally used for thousands of years in Indian Ayurvedic medicine. Ayur – which means life – and Veda – which means knowledge – it is one of the oldest medicines now also recognized by the WHO.
For Ayurvedic medicine there is a harmonic balance between the body and the mind and the spirit; therefore the mental and emotional factors of the person are considered fundamental for the development of the disorder as well as for the cure (3).
Bacopa it is also called Brahmi in India. The name Brahmi comes from the word “Brahma”, the “Supreme Creator” according to Hindu mythology. For this tradition, the brain has been the central organ for creativity and the intellect, hence Bacopa, which is used by Ayurvedic medicine to improve brain health, it is called Brahmi (4). Bacopa monnieri belongs to the Scrophulariaceae family, it is a marsh plant creeping. The plant have been used for centuries for the enhancement of memory (5).
Bioactive principles – The main bioactive components of Bacopa monnieri are Bacosides A and B. These saponins are believed to be responsible for the pharmacological effects attributable to this species (4). Bacopa present in Memorens® is titled 20% in Bacosides.
Therapeutic properties – Bacopa extract improves memory and cognitive functions and can be useful in promoting relaxation and maintaining mental well-being (4,5).
Mechanism of action – Pre-clinical studies have shown an effect on the cholinergic system
through an inhibitory action of acetylcholinesterase (AChE), enzyme involved in the degradation of acetylcholine. Therefore, an increased availability of this important neurotransmitter is involved in the processes of memory. Bacopa also has protective effects as an antioxidant and as an adaptogen (increased resistance to stress) through normalization of plasma cortisol levels and some monoamines such as noradrenaline, dopamine and serotonin, in the hippocampus and in the cerebral cortex, that is, in the areas of the brain most vulnerable to stress (4,6,7).
Tolerability – Bacopa is well tolerated in children. Studies conducted did not showed significant side effects (8,9).
Origin – Eleutherococcus, also called Siberian ginseng, is obtained from the dried hypogea parts (roots and rhizomes) of Eleutherococcus senticosus Rupr. et Maxim (Fam. Araliacee). It is a thorny shrub that grows wild in the eastern regions of Russia, north-eastern China and Japan (3).
Bioactive ingredients – The main active components of Eleutherococcus are a group of compounds called eleutherosides (eleutherosides A-M), of which B and E are responsible for the pharmacological effect. It is thought in fact, that these two compounds are responsible for the adaptogenic properties of Eleutherococcus, (10). The Eleutherococcus present in Memorens® has a title of 0.8% in eleutherosides B + E.
Therapeutic properties – Eleutherococcus is used as a tonic to invigorate and fortifying the body in moments of fatigue and weakness and and when concentration and attention levels are lowered. It has adaptogenic properties, that is, increase the body’s resistance to external stimuli and stress and maintains the natural defenses of the body (11).
Mechanism of action – The adaptogenic effect is related to the regulation of homeostasis through different mechanisms of action associated with the hypothalamus-pituitary-adrenal axis and the control of key biochemical mediators in the stress response (11).
Tolerability – Eleutherococcus is well tolerated. In general, they have been reported only minimal adverse events such as insomnia, irritability, tachycardia and headache, but at doses much higher than those used in clinical practice (12).
Origin – The French Maritime Pine is obtained from the cortex of Pinus pinaster Aiton, subsp. atlantica des Villar, Fam. Pinaceae, a species of pine that grows along the Bay of Biscay in northern France. The cortex is thick, of a brownish-red color, with deep cracks obtained from monocultures that grow over a period of 30-50 years (3).
Bioactive principles – The Maritime Pine extract contains polyphenolic compounds consisting mainly of procyanidins (catechin, taxifolin and oligomers with 7 or more flavonoid units) which exert a significant antioxidant activity and free radical scavenging against reactive oxygen and nitrogen species (13). Memorens® contains a dry extract of Pinus pinaster titled at 95% in OPC (proanthocyanidolic oligomers).
Therapeutic properties – Maritime Pine extract exerts protective effects against oxidative stress, both by increasing the synthesis of antioxidant enzymes and acting as a free radical scavenger.
Mechanism of action – The Maritime Pine extract carries out its antioxidant activity by increasing the synthesis of enzymes such as catalase, superoxide dismutase and glutathione peroxidase which degrade the products from oxidative stress. The Maritime Pine also has anti-inflammatory activity preventing the release of pro-inflammatory mediators regulated by the oxidative stress such as the inducible NO synthetase enzyme, which it produces a high amount of nitrogen monoxide (NO) and pro-inflammatory activity, NF-kβ (nuclear factor kβ), an intracellular factor that is activated by several inflammatory mediators such as TNF-α, IL-1 α, IL-1β, IL-8, and IL-6. It has also been shown that in children with ADHD, the Maritime Pine reduces hyperactivity, excretion of catecholamines and oxidative stress (13).
Tolerability – Maritime Pine is well tolerated. Out of a total of 2000 patients, only 1.5% reported mild side effects such as intestinal disorders, dizziness, headache (3).
Royal jelly is a precious food that is produced by bees. It’s a lot rich in vitamins, rapidly assimilable sugars, unsaturated fats useful for health, completely natural amino acids and proteins, vitamins and minerals which make it an excellent tonic to counteract fatigue, asthenia and loss of appetite in children. Royal jelly has no contraindications.
It is a standardized phytocomplex that contains the active principles of Passiflora (Passiflora incarnata L., herba) and Artichoke (Cynara scolymus L., folium).
Therapeutic properties – Pre-clinical studies show that the mechanism of action at the base of the anxiolytic effects of Passiflora incarnata can be mediated through the modulation of the GABA system (14).
Mechanism of action – Pre-clinical studies show that the mechanism of action at the base of the anxiolytic effects of Passiflora incarnata can be mediated through the modulation of the GABA system (14).
Tolerability – Passiflora incarnata is generally well tolerated. No adverse event seems to have been reported for products registered in the EU (14).
Therapeutic properties – Artichoke helps purify the body. Has hepatoprotective properties, antioxidants and promotes the elimination of intestinal gas (15).
Mechanism of action – At present, the mechanism of action of the Artichoke and its main compounds cannot be considered clarified (15).
Tolerability – Preparations containing Artichoke are generally well tolerated. No major adverse events were reported from clinical pharmacology studies on humans with preparations containing Artichoke leaf extracts. Clinical studies involved over 1600 subjects with a study duration of up to 2 years (15).
- Quesada AA, et al. Psychosocial stress exposure impairs memory retrieval in children. Psychoneuroendocrinology, (2012); 37(1):125-36
- Reid Chassiakos, et al. Children and Adolescents and Digital Media. Pediatrics, (2016); 138 (5): e1-e18
- Fitoterapia, impiego razionale delle droghe vegetali, Capasso, Grandolini, Izzo, Springer-Verlag Italia, 2006
- Shinomol GK, et al. Exploring the Role of “Brahmi” in Brain Function and Therapy. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2011, Vol. 5, No. 1
- Singh HK & Dhawan BN, Neuropsychopharmacology effects for the ayurvedic nootropic Bacopa monniera Linn. Indian Journal of Pharmacology, 1997, 29 (5): 359-365
- Rajan KE, et al. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). Neurochem Res. (2011) Nov;36 (11):2136-44
- Saraf MK, et al. Bacopa monniera Attenuates Impairment of Spatial Memory in Mice. Evid Based Complement Alternat Med. 2011; 2011:1-10.
- Kean JD, et al. A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations. Complement Ther Med. (2016) Dec;29:56-62
- Tora Mitra-Ganguli, et al. A randomized, double-blind study assessing changes in cognitive function in Indian school children receiving a combination of Bacopa monnieri and micronutrient supplementation vs. placebo. Frontiers in Pharmacology, (2017), 8, 678: 1-13
- Załuski D, et al. HPTLC-profiling of eleutherosides, mechanism of antioxidative action of eleutheroside E1, the PAMPA test with LC/MS detection and the structure–activity relationship. Saudi Journal of Biological Sciences (2018) 25, 520–528
- Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. (2009); 4(3): 98-219
- EMA Assessment report on Eleutherococcus senticosus (Rupr. Et Maxim.) Maxim., Radix. (2014) EMA / HMPC / 680615/2013
- Iravani S, Zolfaghari B. Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract. Res Pharm Sci.; (2011), 6 (1): 1-11
- EMA Assessment report on Passiflora incarnata L., herba EMA/HMPC/669738/2013
- EMA Assessment report on Cynara scolymus L., folium EMA/HMPC/150209/2009